Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

9.1 Introduction

Male sexuality is decided genetically during the time of fertilization because of the existence of the Y chromosome into the spermatozoan because it fuses using the X-chromosome-containing ovum, in addition to sex-determining area associated with Y chromosome (SRY) then drives the bipotential gonad associated with the embryo to be a testis through hormone-independent mechanisms 1,2. Nevertheless, after the very early testis is formed, growth of the full male phenotype, including further testicular development (masculinization), becomes totally determined by a complex system of hormonal signals, especially hormones secreted through the testes 2. Individuals who lack any gonads are phenotypically female 1 and endocrine intervention is needed to alter the standard feminine phenotype in order to become male 2.

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